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Background: Non-surgical management of anal cancer by radiotherapy alone or combined with chemotherapy has, in uncontrolled studies, yielded similar local tumour control and survival rates to surgery. However, whether the addition of chemotherapy improves outcome without adding to morbidity is not known. Our trial was deed to compare combined modality therapy CMT with radiotherapy alone in patients with epidermoid anal cancer.
We assessed clinical response 6 weeks after initial treatment: good responders were recommended for boost radiotherapy and poor responders for salvage surgery. Analysis was by intention-to-treat. Findings: In the radiotherapy and CMT arms, respectively, five and three were ineligible, and six and nine Anal during party 6 weeks after initial treatment. The risk of death from anal cancer was also reduced in the CMT arm 0. There was no overall survival advantage 0. Interpretation: Our trial shows that the standard treatment for most patients Anal during party epidermoid anal cancer should be a combination of radiotherapy and infused 5-fluorouracil and mitomycin, with surgery reserved for those who fall on this regimen.
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RSS Link Copy. Full text links Cite Display options Display options. Anal during party Background: Non-surgical management of anal cancer by radiotherapy alone or combined with chemotherapy has, in uncontrolled studies, yielded similar local tumour control and survival rates to surgery. Comment in Combined radiotherapy and chemotherapy for anal cancer.
Bosset JF, et al. PMID: No abstract available. Similar articles [Epidermoid carcinomas of anal canal treated with radiation therapy and concomitant chemotherapy 5-fluorouracil and cisplatin ]. Deniaud-Alexandre E, et al. Cancer Radiother. Epub Nov PMID: French.
Concomitant radiotherapy and chemotherapy is superior to radiotherapy alone in the treatment of locally advanced anal cancer: of a phase III randomized trial Anal during party the European Organization for Research and Treatment of Cancer Radiotherapy and Gastrointestinal Cooperative Groups. Bartelink H, et al. J Clin Oncol. Radiochemotherapy in the conservative treatment of anal canal carcinoma: retrospective analysis of and radiation dose effectiveness.
Ferrigno R, et al. PMID: Valentini V, et al. Radiol Med. PMID: Review. Synchronous chemotherapy and radiotherapy for carcinoma of the anal canal--an alternative to abdominoperineal resection. Tiver KW, et al. Aust N Z J Surg. See all similar articles.
Cited by articles Pulse-dose-rate interstitial brachytherapy in anal squamous cell carcinoma: clinical outcomes and patients' health quality perception. Bourdais R, et al. J Contemp Brachytherapy. Epub May Gotfrit J, et al. Curr Oncol. Arcadipane F, et al.
J Pers Med. Carr RM, et al. Cancers Basel. Anal during party population-based analysis of chemoradiation versus radiation alone in the definitive treatment of patients with stage I-II squamous cell carcinoma of the anus. Parzen JS, et al. J Gastrointest Oncol. See all "Cited by" articles. Publication types Clinical Trial Actions.
Comparative Study Actions. Multicenter Study Actions. Randomized Controlled Trial Actions. Research Support, Non-U. Gov't Actions. MeSH terms Adult Actions. Aged Actions.
Aged, 80 and over Actions. Combined Modality Therapy Actions. Female Actions.
Humans Actions. Male Actions. Middle Aged Actions. Survival Rate Actions. Treatment Outcome Actions. Substances Mitomycins Actions. Fluorouracil Actions. Full text links [x] Elsevier Science. Copy Download.Anal during party
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