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The drug comes with the risk of several serious side effects, including tardive dyskinesia, a condition involving involuntary facial and body movements. InReglan was estimated to be used by more than 2 million Americans.

Board-certified physicians medically review Drugwatch content to ensure its accuracy and quality. PRN is a nationally recognized leader in providing independent medical reviews. Reviewer specialties include internal medicine, gastroenterology, oncology, orthopedic surgery and psychiatry. An antiemetic is a drug that is used to treat vomiting and nausea, conditions that can cause vomiting and nausea, or vomiting and nausea caused by certain drug treatments, such as chemotherapy or general anesthetics.

Reglan was approved by the U. It is available in orally disintegrating tablets or injections. However, the brand-name oral solution is no longer available. The generic version of Reglan, named after its active ingredient metoclopramide and made by several different manufacturers, is available in both tablet form and oral solution.

Treatment with Reglan may result in adverse reactions including a very serious condition called tardive dyskinesia TD. TD Gl black guy looking for white bbw on the side a disorder affecting certain muscles in the body, resulting in involuntary, repetitive body movements that may include grimacing, sticking out the tongue or smacking the lips.

Reglan treats conditions affecting the gastrointestinal tract including gastroesophageal reflux also commonly called GERD and diabetic gastroparesis. Reglan is prescribed for short-term use in patients with GERD who fail to respond to more conventional therapies. The drug can also provide relief of symptoms to patients with acute sudden and severe and recurrent occurring often or repeatedly diabetic gastroparesis, a condition that occurs when the stomach takes too long to empty food.

Reglan has also been found to be effective in treating other conditions involving nausea and vomiting as well as nausea and vomiting associated with the use of certain medications. It does not involve a blockage, or stomach or gastrointestinal obstruction, of any kind.

It can also occur after some surgeries. However, the exact cause of gastroparesis is unknown, but it may be the result of a disruption of nerve als to the stomach, according to the National Institutes of Health NIH. Certain medicines may work to block these nerve, als causing the complication to occur. It is estimated that approximately 5 million people in the United States are affected by gastroparesis. Possible serious complications of gastroparesis can result from ongoing nausea and vomiting or poor blood sugar control in people with diabetes.

Heartburn is also called acid indigestion. It is a burning sensation in the central part of the chest or upper central abdomen. The pain can also be felt in the neck, throat or jaw area. Other symptoms of GERD might include a feeling that food is stuck behind the breastbone, or nausea after eating. Reglan works in the digestive tract in different ways. For gastroparesis, Reglan works by affecting different receptors in the gastrointestinal GI tract, including a dopamine receptor that has a relaxant effect on the gut.

Overall, the drug facilitates increased gastric emptying by enhancing contractions in the stomach and small intestine and decreasing relaxation in part of the stomach after meals. Although Reglan works in most of the GI tract, it has little to no effect on the colon. The drug does, however, increase the tightness of the esophageal sphincter or muscular ring that closes the esophagus when food is not being swallowedwhich prevents the contents of the stomach from coming back up into the esophagus GERD. It can also act to relieve nausea and vomiting by blocking dopamine receptors in the brain.

Dopamine is a neurotransmitter, or chemical messenger, in the brain that controls the reward and pleasure centers. Thereby, dopamine receptors are able to activate the part of the brain that controls nausea and vomiting. By blocking those receptors, patients may be alleviated of symptoms. In approximately 10 percent of patients given 10 mg of Reglan metoclopramide four times daily, the most commonly reported side effects included restlessness, drowsiness, fatigue and lassitude mental weariness or lack of energy. The incidence of such adverse reactions was dependent upon dosage and duration of drug exposure.

Some adverse reactions occurred after Reglan treatment was discontinued, especially involving the nervous system. These side effects included dizziness, nervousness and headaches. Use of Reglan, especially for longer than 12 weeks, carries the risk of developing a condition known as tardive dyskinesia TDa neurological disorder that involves involuntary, rapid movements of the face and body. Depending on the person, TD symptoms may be mild and only last for a short time or they may continue indefinitely. Gl black guy looking for white bbw on the side the condition is diagnosed early enough, changing medications may be enough.

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In some instances, however, it can be permanent. According to an FDA study conducted ina of patients were prescribed Reglan for long-term use defined as longer than 3 months and this increased the of people who suffered side effects, including TD. The incidence of TD in long-term Reglan users is cited to be as high as 20 percent in Gl black guy looking for white bbw on the side literature. This led to the FDA requiring a black-box warning in The warning advises patients about the dangers of developing tardive dyskinesia after long-term use of Reglan and its generic counterparts.

The FDA recommends avoiding treatment with Reglan for longer than 12 weeks, but rare cases may arise in which the therapeutic benefit of the drug is deemed to outweigh the risk of TD. Its use should be discontinued in patients who develop s of TD. In some instances, taking the drug can suppress or partially suppress the s of TD, masking the underlying disease process. If you have kidney problems, your doctor may opt to prescribe a lower dose.

For patients with liver problems and heart failure, Reglan may cause the body to retain fluids. And in diabetics, patients taking Reglan may have to have their insulin dose adjusted. According to the FDA, it is not known if Reglan will harm fetuses. It can pass into breast milk and may harm a breast-feeding infant. Still, according to some reports, nursing mothers have taken drugs, including Reglan, to help them produce more milk, even though doctors say this can be risky. Lactation consultants have prescribed the drugs, saying they can increase the hormone responsible for breast milk production, prolactin.

Reglan comes in two tablet strengths — 5 milligrams and 10 milligrams. Patients being treated for gastroesophageal reflux also more commonly known as acid reflux should take the recommended dose of Reglan four times a day, either continuously or intermittently as neededor at specific times of the day.

The recommended adult dosage of Reglan is 10 to 15 mg taken four times daily for four to 12 weeks. Reglan works best for acid reflux if taken 30 minutes before each meal and at bedtime. Patients using Reglan to treat acid reflux should not take more than the maximum recommended daily dosage of 60 mg. If taken intermittently, or only as symptoms occur, a single dose of Reglan up to 20 mg can be administered as the situation warrants.

Reglan dosages should be taken 30 minutes before each meal and at bedtime.

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Patients with gastroparesis should not take more than the maximum recommended daily dosage of 40 mg of Reglan. If patients with diabetic gastroparesis suffer from severe nausea or vomiting and are unable to take Reglan tablets orally, treatment with Reglan can begin by injection. These injections can be given intramuscularly administered directly into the muscle or intravenously for up to 10 days. After patients are able to take Reglan orally, treatment should continue with Reglan tablets for no longer than 12 weeks of total treatment time.

Elderly patients may be more sensitive to the effects of Reglan.

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A lower starting dosage of 5 mg taken four times a day is recommended. Reglan may also affect the clinical efficacies of certain medications in patients. Using Reglan along with other medications can also lead to an increased risk of certain side effects or unknown adverse reactions. Calling this connects you with a Drugwatch representative. We will direct you to one of our trusted legal partners for a free case review. Drugwatch's trusted legal partners support the organization's mission to keep people safe from dangerous drugs and medical devices.

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Medically Reviewed. Reglan treats: Slow stomach emptying in people with diabetes, also known as gastroparesis Nausea and vomiting that can happen with cancer chemotherapy Nausea and vomiting that may happen after surgery in patients whose doctors do not want them treated with a stomach tube and suction What Is Gastroparesis? Symptoms of the condition include: Nausea Vomiting Bloating abdominal distention or premature abdominal fullness after meals Abdominal pain Heartburn Anorexia eating disorder characterized by self-starvation and excessive weight loss Weight loss without trying Hypoglycemia abnormally low levels of blood sugar in patients with diabetes.

These complications can include: Dehydration Electrolyte imbalances Malnutrition Diabetes complications. What is GERD? When food and stomach acids back up into the esophagus, it may lead to heartburn and other symptoms.

Less common symptoms of the condition include: Bringing food back up regurgitation Coughing or wheezing high-pitched whistling sound made when a person breathes Difficulty swallowing Hiccups Hoarseness or voice changes Sore throat. Symptoms may be worse at night, or when a person bends over or lays down, or after eating. Reglan affects different receptors in the GI tract in order to facilitate gastric emptying. Gastroesophageal Acid Reflux Patients being treated for Gl black guy looking for white bbw on the side reflux also more commonly known as acid reflux should take the recommended dose of Reglan four times a day, either continuously or intermittently as neededor at specific times of the day.

Dosage Adjustments and Elderly Patients Dosage adjustments should be made for patients with the following conditions: Moderate to severe liver impairment Moderate to severe kidney impairment End-stage kidney disease Those who poorly metabolize CYP2D6 an enzyme primarily associated with the liver. Dosage adjustments should also be made for those taking strong CYP2D6 inhibitors, such as: Quinidine heart medication — helps the heart beat regularly. Bupropion used to help people quit smoking.

Reglan Overdose There is no specific antidote reversal agent for Reglan overdose. Symptoms of Reglan overdose can include: Drowsiness Disorientation Extrapyramidal reactions drug-induced movement disorders Other adverse reactions associated with Reglan-use Death. Medications that may interact with Reglan include: Insulin Antipsychotics Strong CYP2D6 inhibitors — Quinidine, bupropion, fluoxetine, paroxetine Monoamine oxidase inhibitors MAOIs Central nervous system CNS depressants — Alcohol, sedatives, hypnotics, opiates, anxiolytics Drugs that impair gastrointestinal motility — Antiperistaltic antidiarrheal drugs, anticholinergic drugs, opiates Dopaminergic agonists and other drugs that increase dopamine concentrations — Apomorphine, bromocriptine, cabergoline, levodopa, pramipexole, ropinirole, rotigotine Succinylcholine, Mivacurium Drugs with absorption altered due to increased gastrointestinal motility — Drugs with decreased absorption include digoxin, atovaquone, posaconazole oral suspension, fosfomycin.

Drugs with increased absorption include sirolimus, tacrolimus, cyclosporine. Reglan Facts. Please seek the advice of a medical professional before making health care decisions. Related s. Yes No. Thank you for your feedback.

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