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Publication date Electronic : 07 October Publisher: Elsevier. Data availability:. Keywords: bromhidrosishyperhidrosismicrowavemiradrytrimethylaminuriadlqi, dermatology life quality indexfmo3, flavin mono-oxygenase 3tma, trimethylaminetmau, trimethylaminuria.

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Review article Invite someone to review. There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience. Introduction Bromhidrosis is known as foul-smelling perspiration with or without hyperhidrosis.

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Apocrine bromhidrosis is the result of apocrine sweat being degraded by cutaneous bacteria, leading to ammonia and short-chain fatty acids. In contrast, eccrine bromhidrosis in various distinguishing odors unique to its primary cause: bacterial degradation of the stratum corneum, metabolic disorders, or the ingestion of odorgenic foods such as garlic and asparagus. This in the inability to properly metabolize trimethylamine TMA to trimethylamine-N-oxide. Consequently, a build-up of excessive TMA, which has a fishy odor, is eventually excreted through bodily fluids such as perspiration, giving the Tmau dating site a characteristic foul odor Fig 1.

The overabundance of TMA is eventually excreted through body fluids including urine and sweat, resulting in a foul fish-like odor. TMAU can have a ificant impact on an individual's quality of life and predisposes those affected to self-isolation, depression, and psychosocial stress. Patients are often forced to avoid foods that contain precursors of TMA or inhibitors of FMO3, such as eggs, seafood, legumes, and soy, in an attempt to reduce their bromhidrosis, but this can be difficult to do and minimally effective.

The treatment is a Tmau dating site procedure that uses controlled microwave-generated thermal energy to create heat within the reticular dermis and subcutaneous tissue, thus destroying adnexal structures, including apocrine and eccrine sweat glands.

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Two treatments, 2 to 3 months apart, are generally required to achieve satisfying in the average patient. We present the case of a year-old woman in whom trimethylaminuria was diagnosed at the age of 19 years who received MiraDry to nonselectively destroy her sweat Tmau dating site, ificantly reducing her bromhidrosis with satisfying. Case report A year-old woman presented to our clinic with the chief complaint of severe bromhidrosis secondary to a metabolic disorder, TMAU, involving the axilla and groin. She reported that around the age of 16 years, she began experiencing hyperhidrosis with a foul odor, which was diagnosed when she was 19 years old as TMAU.

The patient found her condition, particularly the axillary bromhidrosis, to be severely socially debilitating because she was very self-conscious about the odor and whether others around her could perceive it.

As a result, she restricted herself from public areas and would go out only immediately after showering. She became ashamed of her body and felt like she was unable to participate in normal activities such as going to the Tmau dating site, dating, and socializing with friends. She had ed multiple support groups and was seeing a psychologist regularly because her self-isolation resulted in her becoming increasingly depressed.

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Before presenting to us, she had tried topical aluminum chloride, which was ineffective. She did not want to try oral anticholinergics because of possible adverse effects.

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After careful review of all of the possible adverse effects associated with the treatment, the patient believed that this would be her only permanent option for improvement. On the treatment day, the patient received tumescent anesthesia, and both axillae were gridded with a template, according to the manufacturer's recommended protocol, indicating where the treatment points would be.

The device was set to a setting of 5 for both axilla. She tolerated the procedure and experienced mild pinpoint bleeding from the anesthesia insertion points. For about 1 week after the procedure, she was markedly swollen, which is an expected response. She did not experience any prolonged numbness, tingling, or paresthesia. A second treatment was offered at that time, and the patient returned 10 weeks later. Discussion Although TMAU and bromhidrosis are not life-threatening conditions, the resulting symptoms may have considerable negative psychosocial consequences.

As evident with the patient described in this case report, affected individuals may suffer from anxiety, depression, social isolation, and low self-esteem. However, noninvasive treatments such as botulinum toxin injections and topicals offer only temporary solutions, and invasive treatments such as thoracic sympathectomy, subcutaneous shaving, and tumescent liposuction may lead to adverse effects, including compensatory hyperhidrosis, ificant scarring, infection, and restricted arm movement. As a treatment that offers the possibility of long-term efficacy with mild adverse effects, this microwave-based technology is a favorable option for axillary bromhidrosis secondary to Tmau dating site and, possibly, other metabolic or genetic disorders that result in various forms of hyperhidrosis or bromhidrosis.

Negative Pressure Wound Therapy Journal. Background A third-generation microwave-based device has been developed to treat axillary hyperhidrosis by selectively heating the interface between the skin and underlying fat where Tmau dating site sweat glands reside. Materials and Methods Thirty-one 31 adults with primary axillary hyperhidrosis were enrolled.

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All subjects had one to three procedure sessions over a 6-month period to treat both axillae fully. Subject safety was assessed at each visit. Subjects were followed for 12 months after all procedure sessions were complete. At the month follow-up visit, All subjects experienced transient effects in the treatment area such as swelling, discomfort, and numbness. The most common adverse event 12 subjects was the presence of altered sensation in the skin of the arm that resolved in all subjects. Conclusion The device tested provided efficacious and durable treatment for axillary hyperhidrosis.

Record : found Abstract : not found Article : not found. Tmau dating site references. Contributors Forum Patel.

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ISSN Electronic : Publication date PMC-release: 07 October Publication date Collection: October Published by Elsevier, Inc. Subject: Case Report. Variants in the flavin-containing monooxygenase 3 FMO3 gene responsible for trimethylaminuria in a Japanese population. Human flavin-containing monooxygenase form 3: cDNA expression of the enzymes containing amino acid substitutions observed in individuals with trimethylaminuria.

A low initial botulinum toxin A treatment response does not predict poor long-term Tmau dating site in patients with axillary bromhidrosis. See all similar. Y Chen C. TU See all reference authors. Version 1.

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