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Opioid-naive patients: 2. Neonates: 0. Hypersensitivity to methadone or formulation components; acute abdominal condition, toxin-mediated diarrhea, pseudomembranous colitis, respiratory depression; concurrent use of selegiline, hypercarbia, known or suspected gastrointestinal obstruction, including paralytic ileus, asthma acuteificant respiratory impairment. Schedule II opioid analgesics expose users to the risks of addiction, abuse, and misuse; there is a greater risk for overdose and death with extended-release opioids due to the larger amount of active opioid present see Black Box Warnings.
Opioids can cause sleep-related breathing disorders including central sleep apnea CSA and sleep-related hypoxemia; opioid use increases risk of CSA in a dose-dependent fashion; in patients who present with CSA, consider decreasing opioid dosage using best practices for opioid taper. Addiction, abuse, and misuse risks are increased in patients with a personal or family history of substance abuse or What forms does methadone come in illness eg, major depression ; the potential for these risks should not, however, prevent the prescribing of proper pain management in any given patient; intensive monitoring is necessary see Black Box Warnings.
May cause constipation, which could cause problems in patients with unstable angina and patients post-myocardial infarction; consider preventive measures sool softener, increased fiber in diet to reduce potential for constipation. Do not abruptly discontinue buprenorphine in a patient physically dependent on opioids; when discontinuing therapy, in a physically dependent patient, gradually taper the dosage; rapid tapering in a patient physically dependent on opioids may lead to a withdrawal syndrome and return of pain. Neonatal opioid withdrawal syndrome reported with long-term use during pregnancy see Black Box Warnings.
Interactions with CNS depressants eg, alcohol, sedatives, anxiolytics, hypnotics, neuroleptics, other opioids can cause additive effects and increase risk for respiratory depression, profound sedation, and hypotension; deaths reported due to methadone abuse in conjunction with benzodiazepines.
Monitor for hypotension during dose initiation and titration; use with What forms does methadone come in in patients with hypovolemia, cardiovascular disease including acute MIor drugs which may ificantly increase hypotensive effects. In patients with circulatory shock, therapy may cause vasodilation that can further reduce cardiac output and blood pressure; avoid therapy in patients with circulatory shock. Life-threatening respiratory depression is more likely to occur in elderly, cachectic, or debilitated patients as they may have altered pharmacokinetics or altered clearance compared to younger, healthier patients.
Not recommended to treat abdominal conditions; may obscure diagnosis or clinical course of patients with acute abdominal conditions. May obscure diagnosis or clinical course of patients with acute abdominal conditions; avoid use in patients with obstruction.
Use with caution in patients with biliary tract dysfunction, including acute pancreatitis; may cause constriction of sphincter of Oddi. There are no adequate and well-controlled studies in pregnant women; untreated opioid addiction is associated with adverse obstetrical outcomes such as low birth weight, preterm birth, and fetal death; in addition, untreated opioid addiction often in continued or relapsing illicit opioid use; neonatal opioid withdrawal syndrome NOWS is an expected and treatable outcome of prolonged use of opioids during pregnancy.
Pregnant women in methadone maintenance programs may have reduced incidence of obstetric and fetal complications and neonatal morbidity and mortality when compared to women using illicit drugs; untreated opioid addiction in pregnancy is associated with adverse obstetrical outcomes and risk of continued or relapsing illicit opioid use; these risks should be considered in women receiving maintenance treatment of opioid addiction; for women treated with pain severe enough to require daily, around-the-clock, long-term opioid treatment, therapy should be What forms does methadone come in during pregnancy only if potential benefit justifies potential risk to fetus.
Narcotic agonist-analgesic of opiate receptors; inhibits ascending pain pathways, thus altering perception and response to pain; produces analgesia, respiratory depression, and sedation. Adding plans allows you to compare formulary status to other drugs in the same class.
To view formulary information first create a list of plans. Your list will be saved and can be edited at any time. The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information. By clicking send, you acknowledge that you have permission to the recipient with this information. For You. Decision Point. Log In. Up It's Free! Register Log In.
No. If you log out, you will be required to username and password the next time you visit. Log out Cancel. Brand and Other Names: Methadose, Dolophine. Share Print Feedback Close. Sections methadone. Pain 2. ificant - Monitor Closely. Controlled studies in pregnant women show no evidence of fetal risk. B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or What forms does methadone come in animal nor human studies done.
Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available. Patient Handout.
Print without Office Info. Print with Office Info. Formulary Formulary Patient Discounts. Create Your List of Plans. View explanations for tiers and restrictions. Tier Description 1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs. Most commonly, these are "preferred" on formulary brand drugs.
Most commonly, these are "non-preferred" brand drugs. Most commonly, these are "non-preferred" brand drugs or specialty prescription products. This restriction requires that specific clinical criteria be met prior to the approval What forms does methadone come in the prescription. QL Quantity Limits Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered. ST Step Therapy Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
OR Other Restrictions Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription. Non-Medicare Plans Medicare Plans. From: To:. Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.
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You are being redirected to Medscape Education. Need a Curbside Consult? Share cases and questions with Physicians on Medscape consult. Share a Case. This drug is available at a middle level co-pay.
This drug is available at a higher level co-pay. Prior Authorization Drugs that require prior authorization. Quantity Limits Drugs that have quantity limits associated with each prescription. Step Therapy Drugs that have step therapy associated with each prescription. Other Restrictions Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.What forms does methadone come in
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